Welcome to the Laboratory for Systems Medicine
The newly established Laboratory for Systems Medicine at University of Florida Health is focused on computational and mathematical approaches to human health.
The Laboratory for Systems Medicine was established in 2020 as an initiative funded by the Department of Medicine and the Office of the President of UFHealth. The overarching focus is the development and application of mathematical and computational technology for the improvement of human health. Interests include multi-scale modeling and control of disease processes, systems biology, and computational immunology. We are highly collaborative, maintaining and seeking partnerships with clinical, basic science, computational, and private sector labs and entities. Our expertise includes the development of mechanistic and data-driven multi-scale models of disease-relevant processes, model-driven control and optimization problems, and cutting-edge data science methods applied to high-dimensional data from the molecular to the patient scale.
Systems medicine News
PUBLICATION
Toward mechanistic medical digital twins: some use cases in immunology
Digital twin technology for health applications is still in its infancy, and extensive research and development is required. This article focuses on several projects in different stages of development that can lead to specific—and practical–medical digital twins or digital twin modeling platforms.
PUBLICATION
Forum on immune digital twins: a meeting report
Medical digital twins are computational models of human biology relevant to a given medical condition, which are tailored to an individual patient, thereby predicting the course of disease and individualized treatments, an important goal of personalized medicine. The immune system, which has a central role in many diseases, is highly heterogeneous between individuals, and thus poses a major challenge for this technology. In February 2023, an international group of experts convened for two days to discuss these challenges related to immune digital twins.
PUBLICATION
SimService: A Lightweight Library for Building Simulation Services in Python.
Integrative biological modeling requires software infrastructure to launch, interconnect, and execute simulation software components without loss of functionality. SimService is a software library that enables deploying simulations in integrated applications as memory-isolated services with interactive proxy objects in the Python programming language. SimService supports customizing the interface of proxies so that simulation developers and users alike can tailor generated simulation instances according to model, method, and integrated application.
PROMOTION
The UF Laboratory for Systems Medicine congratulates Dr. Luis Sordo Vieira on his promotion to Assistant Professor of Medicine.
UPCOMING/RECENT PRESENTATIONS
SEMINAR PRESENTATION
Determinants and Mediators of Racial-Ethnic Differences in Post–Lung Transplant Outcomes
Date: 1/11/24
Venue: UF Pulmonary Research Conference Seminar Series, Gainesville, FL
Presenter: Jason Cory Brunson
SEMINAR PRESENTATION
Treatment Optimization in Medical Digital Twins
Date: Oct 25, 2023
Venue:Â UF Pulmonary Research Conference Seminar Series, Gainesville, FL
SEMINAR PRESENTATION
How to Calculate an Optimal Drug Regimen
Date: Oct 18, 2023
Venue:Â UF Pulmonary Research Conference Seminar Series, Gainesville, FL
Moderated Discussion
Research!America Alliance Discussion on Digital Twins
What is a digital twin? Learn more at this Research!America Alliance Discussion on June 15 @ 11:30 am – 12:00 pm.
Upcoming Seminars
Tuesday March 12, 2024
Wenrui Hao, Ph.D., Associate Professor
Harness computational modeling to understand biomedical diseases
TUESDAY March 19, 2024
Marissa Renardy, Ph.D., Principal Scientist
A multi-scale semi-mechanistic CK/PD model for CAR T-cell therapy
Thursday March 21, 2024 at 9:00 AM Eastern Time
Eirini Tsirvouli, Researcher & Ph.D. Candidate
Dynamic Boolean modeling of psoriasis
Tuesday, April 2, 2024
Yong Huang, Ph.D., Professor
Novel Implementation of Three-Dimensional Bioprinting
Current Research Projects
MARK TERASAKI, JASON CORY BRUNSON, KRISTINA SUAREZ
Structure and development of glomerular capillaries
Topological modeling and simulation lend insight into the structure, development, function, and resilience of glomerular capillary networks.
YARA SKAF, OSAMA DASA, JASON CORY BRUNSON
Exploring Clinical Outcomes using Topological Data Analysis
In this project, we demonstrate how topological data analysis can be used to visualize, explore, and characterize large and complex biomedical data such as electronic health records.
LUIS SORDO VIEIRA, CAROL A. MATHEWS
Predicting Populations At-Risk of Developing Pathological Hoarding
This study will identify risk-factors for developing troublesome hoarding by integrating and analyzing clinical interviews and a web-based registry of adults that includes various medical and cognitive questionnaires and neurocognitive.
HENRIQUE DE ASSIS L RIBEIRO, ADAM C KNAPP, LUIS L FONSECA
Multi-scale Modeling of the Immune Response to Aspergillus Fumigatus
Multi-scale agent-based modeling of the immune response and battle over iron in Aspergillus fumigatus infection.
we are hiring!
We are hiring!
The newly established Laboratory for Systems Medicine at University of Florida Health is focused on computational and mathematical approaches to human health.